Testing the particle characterization of pharmaceutical products is a complex set of procedures associated with high costs, time, and scientific knowledge in order to build quality, efficacy, and safety into the composition of a drug. And the scientific and commercial success of a pharmaceutical product can only be assured with an understanding of Particle shape, size distribution, porosity, and surface area. This knowledge is needed to define and assure the identity, potency, and purity of active ingredients.
Regulatory agencies are realizing the value of particle size distribution, demanding more control and understanding of the physical characteristics of their medicines from drug developers. The dispersion of medicinal substances (drugs) is directly related to their therapeutic effect: with a decrease in the particle size, the surface energy of the crushed drug increases, which dissolves better, participates faster and more fully in chemical reactions. The speed and completeness of drug absorption depend on the particle size, its concentration in biofluids for any method of administration in the form of various drugs.
Particle Shape is measured to increase understanding and control of manufacturing processes. Two particles may be the same size, but their shape may differ, which can impact their behavior or performance. Particle shape can detect problems during powder flow or particle abrasion. And the knowledge of these characteristics can lead to better development of drugs in the pharmaceutical industry.
Moreover, porosity and surface area are also essential factors in the tableting, processing, purification, packaging, dissolution rate, bioavailability, and shelf-life of pharmaceutical products.
The following are some examples of pharmaceutical materials we have analyzed:
- Excipients
- Emulsions
- Powders
- Suspensions
- Injections
- Topical ointments
- Lotions and creams
- Solid dosage forms
- Active Pharmaceutical Ingredients
